This project aims to comprehensively assess the earthquake hazard and liquefaction risk for urban transformation and building safety in Balıkesir province. Within the scope of the project, geophysical, geological and geotechnical surveys will be conducted in areas with high liquefaction potential and detailed Vs30 maps will be created; liquefaction hazard will be determined and analyzed using lithology and groundwater level data and existing Seismic Hazard Maps will be updated. The data obtained will be used as a basis for building safety and urban planning studies in areas with dense urbanization.

The COVID-19 Project aims to develop effective vaccines and drugs against COVID-19. Within the scope of the project, modern biotechnological methods and molecular biology techniques will be applied, and both preventive and therapeutic solutions will be developed by taking into account the structure of the virus, antigen properties and immune response. In this context, a total of 9 different drug and 7 different vaccine projects will be carried out, and the efficacy and safety of the biological products obtained under each project will be tested in laboratory and preclinical studies. In addition, through these studies, it is aimed to strengthen the domestic biotechnology infrastructure, increase production capacity and develop strategic foresight against epidemics.

This project, which is relevant to the DOKAP region, was set in motion to meet the needs and increase the potential of agricultural organizations in the DOKAP region. TÜBİTAK MAM's Food Technologies Research Group has the necessary infrastructure and expertise to support the R&D and innovative business models of these organizations. In this context, it aims to contribute to the strengthening and capacity building of agricultural organizations in the DOKAP region by conducting research in the light of literature knowledge and known methods.

Within the scope of this project supported by TÜSEB, RNAseq study for marker development in Alzheimer's patients will be carried out. Within the scope of the project, RNAseq study will be performed in Alzheimer's patient samples with Next Generation Sequencing. At the same time, it is aimed to isolate RNA, prepare cDNA libraries and find marker genes by bioinformatic analysis. TÜBİTAK MAM's contribution to the project is to find markers in blood samples for the diagnosis of Alzheimer's patients.

The project aims to develop a Hydrogen Supply Subsystem that will produce, purify and store hydrogen gas for the PEM Fuel Cell System. The project covers system requirements analysis, design, manufacturing, test and integration phases. In this context, studies carried out in areas such as system engineering, project management and quality management contribute to the development of hydrogen technologies and the production of solutions for the needs of the country. The project also includes the design, development, production, testing and integration of the Hydrogen Supply Subsystem, and aims to strengthen Turkey's capacity in the field of hydrogen technologies and develop sustainable energy solutions.

In the project, a study is being carried out to determine the vulnerability of Istanbul Airport to climate change and the measures that can be taken against it. In this context, regional-scale climate simulations and projections are made, and vulnerability and risk analysis related to the airport's activities are carried out. The study includes stakeholder meetings, data collection, climate modeling and scenario analysis. As a result, adaptation measures and an action plan will be presented to increase the adaptive capacity of the airport's infrastructure and operations to climate change.

This project, which will be realized in Izmir province, aims to address coastal areas and interaction areas with an integrated approach, to ensure harmony between coastal functions and activities and coastal targets, to protect the coastal ecosystem in line with the principle of sustainable development and to observe the use of natural resources. Within the scope of the project, transportation infrastructures required to be built on the coast, spatial targets, strategies, action proposals and management plans that will ensure the balance between protection and use will be developed, Monitoring and Strategic Environmental Assessment processes and Marine Spatial Planning studies for Izmir and Nemrut Bays will be carried out. In addition, methods, tools and technical rules will be determined for the preparation of Integrated Coastal Areas Management and Plan in geographical information systems (GIS) environment and management of relevant data and information on a relational and geographical database.

The project uses thermo-chemical catalytic methods to convert carbon dioxide into fuels and aims to design and build a fuel production process and reactor system. The project focuses on the development of novel catalysts and innovative processes. The scope includes testing of the catalyst and reactor systems at semi-pilot scale, process optimization and preliminary design of the demonstration scale plant.

The project aims to assess the current status of the TRIGEN pilot plant in Soma and identify maintenance and overhaul needs. Through field studies, equipment will be function tested and additional systems for hydrogen production will be identified. The project plans to test hydrogen production using low heating value coals with high heating value coals or biomass blends. Blue hydrogen production including carbon sequestration units will also be investigated and a demonstration plant will be established. The project aims to expand the pilot plant for hydrogen production and increase hydrogen production with low heating value coals.

The project aims to quickly and precisely determine the character and behavior of the fracture zone when an earthquake of magnitude 6.0 and above occurs in our country, to determine the distribution of aftershocks and to reveal the tectonic structure that caused the earthquake. Preliminary findings and updated results obtained within the scope of the project will be communicated to the public and relevant authorities. TÜBİTAK MAM will establish Seismology and GPS working groups to observe aftershock activity and post-seismic crustal deformations, establish at least 10 seismology and 5 GPS observation stations in the region where the earthquake occurred, and the data collected will be quickly analyzed by the expert team to investigate the aftershock distribution, post-seismic deformations and faulting character.

Within the scope of the project, it is aimed to synthesize new drug active ingredients (Nimesulide and Ibuprofen derivatives) for the treatment of breast cancer, which is one of the most common cancer types in our country and in the world, to develop high-tech multifunctional nanocarrier systems (PEG-PCL based) and to determine their effectiveness in reaching the target tissue. As a marker to target the nanoparticles to cells, it is planned to use a peptide that has been investigated in recent years and has exhibited positive properties in targeting and has a high potential for clinical use. Within the scope of this project, in addition to the development of new synthetic agents for the treatment of breast cancer, a polymeric micellar nanoparticle system that will carry the drug to the target site will be developed.

The aim of this project supported by TÜSEB is to develop a BCMA-targeted CAR-T cell therapy product. Within the scope of the project, a BCMA-targeted receptor will be designed first. This structure will then be synthesized and cloned into a lentivirus vector. Lentivirus particles will be produced and expressed in the target T cell line. The cytotoxic effect of the CAR-T product on multiple myeloma cells will be demonstrated. In this process, characterization studies of the product will also be completed. It is aimed that the product that will result from the project will be TÜBİTAK MAM's own design and will be more affordable than other equivalent products.

This project aims to develop an indigenous SGIC capable of real-time and continuous monitoring of glucose levels in interstitial fluid. The project includes probe optimization, component design and device performance evaluation of the enzyme-based electrochemical sensor. The SGI system to be developed will enable the prediction of impending episodes of hypoglycemia or hyperglycemia by continuously monitoring changes in glucose levels through the subcutaneous sensor. Within the scope of the project, characterization of the sensor and components, development of the glucose measurement methodology and performance tests will be carried out. In this way, SGIC will facilitate individual patient follow-up and contribute to the public interest by providing cost-effective solutions in the healthcare system.

This project, which is within the scope of TÜBİTAK 1711-Artificial Intelligence Ecosystem Call, aims to recover process wastewater and reduce water and chemical consumption with automation-supported artificial intelligence applications in textile dyeing mills. The project covers the detection of wastewater characteristics arising from different dyeing recipes in textile finishing enterprises with sensors, analysis and processing with artificial intelligence. With the artificial intelligence application to be developed in this context, continuous improvement of dyeing recipes will be ensured, productivity will be increased and the amount of wastewater discharged to the environment will be reduced by separating and reusing wastewater with low pollution load.

TÜBİTAK 1711 – Yapay Zekâ Ekosistem Çağrısı kapsamında olan bu projede, konsantre atıksuyun arıtmadan geri kazanılmasını sağlayan yenilikçi bir yaklaşım geliştirilmiştir. Proje, YSA algoritması tabanlı Karar Destek Sistemi kullanarak boyama proseslerinde atıksuyun yeniden kullanımını hedeflemektedir. Laboratuvar çalışmaları ve pilot sistem geliştirme aşamalarını içeren proje, tekstil endüstrisinin yıllık 7 milyar m³ su tüketimi bağlamında sürdürülebilirliğe katkı sağlamayı amaçlamaktadır. Mevcut durumda atıksuların %65-75’i geri kazanılırken, proje ile bu oranın %95’in üzerine çıkarılması ve uzun vadede yılda 1-1,3 milyar m³ suyun geri kazanımı hedeflenmektedir.

Within the scope of the project, it is aimed to obtain high purity toxin standards, which are mandatory for use in mycotoxin analysis, from fungal sources specific to Turkey. Within the scope of the project, it is planned to produce 10 mycotoxin standards (Aflatoxin B1, B2, G1, G2, OTA, DON, ZEA, Fumonisin B1, B2 and Patulin) with high (analytical) purity. The studies in the project will be carried out by researchers from various institutions and organizations in different disciplines under 4 main work packages

This project, supported under the TÜBİTAK 1007 program, aims to reveal earthquake scenarios that may affect settlement areas by examining the paleoseismological characteristics of Turkey's Resilient Faults. Within the scope of the project, paleoseismology-based studies are carried out on 128 faults and fault segments, and estimated earthquake magnitude and time are determined. The data obtained will fill the gaps in the MTA database and contribute to the updating of the Earthquake Hazard Map of Turkey. Carbon-14 age determination analyses are carried out at the TÜBİTAK MAM AMS Laboratory.

This project, supported by TÜSEB, aims to develop a biocompatible, anti-immunogenic and conductive 3D Cardiac Patch containing cell-free bovine pericardium, silk fibroin and nano gold through biotechnological, biochemical, mechanical and electro-physiological approaches. Within the scope of the project, a functional and mechanically durable patch that supports the movement, proliferation and metamorphosis of cells by creating a biomimetic microenvironment will be designed. Endothelialization, cardiac regeneration and reconstruction will be achieved with the 3D Cardiac Patch to be developed and it is aimed to provide permanent solutions to problems such as post-operative antigenicity, calcification and dysfunction in clinical implant applications.