MAM
Biotechnology Research Teams
Vaccine Technologies Research Team
Vaccine Technologies Research Team conducts studies based on the development of protective and immunotherapeutic treatment methods against biological agents of zoonotic origin or directly affecting human health. Our laboratory has the appropriate infrastructure and expert staff for vaccine development studies in inactive, subunit, recombinant peptide form. In vitro and in vivo studies carried out meticulously in this context include the production of conventional and recombinant toxins, preclinical laboratory-scale vaccine production, examination of vaccine-based humoral and cellular immune responses, modeling of next generation immunotherapeutics, the use of drug and gene-loaded nanocarriers and effective adjuvant systems, development of vaccine-adjuvant formulations and tissue engineering studies. The Vaccine Technologies Research Team contributes to the field of CBRN defense with the development of diagnostic and treatment methods against biological agents and works in line with the needs of public and private sector organizations by providing national/international collaborations.
Areas of Activity and Work
In vitro Cell Culture
Food toxicology, nanotoxicology, biocompatibility, bioefficacy and biosafety determination, anti-microbial and anti-cancer efficacy.
Tissue Engineering, 3D in vitro Modeling, in vitro Immunotherapeutic Modeling
Cell- and molecular-based immunoregulation in inflammatory disease models
Purification and Chemical Synthesis Studies
Peptide synthesis, purification and characterization.
Vaccine-Adjuvant Studies
Stability, antigen-adjuvant compatibility, immunogenicity & dose, innate and adaptive immune response studies.
In Vivo Animal Modeling and Challenge Studies
Mice, rats, guinea pigs, rabbits and ferrets.
Plant Biotechnology Research Team
The Plant Biotechnology Research Team continues its activities within the scope of producing products and services that can be transformed into added value by using up-to-date biotechnology and genetic engineering methods in line with the country's priorities.
The Plant Biotechnology Research Team collaborates with public research institutions, universities and the private sector at national and international level. In addition, analysis and consultancy services are provided to public and private sector organizations.
Areas of Activity and Work
Next Generation Genomic Research
Characterization of national plant genetic resources, studies on increasing productivity and quality values in plants with molecular approaches, elucidation of molecular mechanisms involved in biotic / abiotic stress in plants and identification of molecular markers, molecular marker-assisted breeding programs in plants.
Genomic rearrangements in plants
Plant cell suspension and tissue culture applications, production of valuable plant metabolites in plant-based sustainable systems (such as bioreactors) and regulation of their quantities by genetic manipulation.
RNAi
The use of microbial agents in the treatment and prevention of plant diseases.
Biomaterials Research Team
Biomaterials Research Team is a multidisciplinary research team that aims to develop innovative solutions in biomaterials and biotechnology applications. Our team works towards the realization of technologies, products and services with high competitiveness and added value that our country needs in various disciplines such as health, food safety and environmental protection. Our research includes studies on new functional biomaterials for therapeutic and diagnostic purposes, as well as drug delivery systems, development of synthetic drugs and imaging agents, biosensor technologies and diagnostic kits that offer innovative approaches in the early detection and treatment of diseases. We also provide innovative solutions in the field of tissue engineering and regenerative medicine by focusing on the imitation of natural processes through biomimetic and regenerative medicine research, while integrating nanostructures and smart materials in the field of nanotechnology and materials science into healthcare technologies.
Areas of Activity and Work
For the Treatment of Diseases
Development of synthetic drug molecules, nanocarrier systems, drug formulations and targeted therapeutic agents.
Detection of Diseases and Infections
Biosensor and Diagnostic Kits, Pet imaging agents development studies.
Nanotechnology and Materials Science
Tissue Engineering and biomimetic materials, Antimicrobial Coatings, Nanocomposite Biomaterials, Nanofiber Mask Filters, Antimicrobial Nanofibers, Antimicrobial Hydrogels, 3D Bioprinting Technology, Bioink, Wound dressings, Artificial Skin Graft, Smart Food Packaging and Smart Packaging Labels.
Animal Biotechnology Research Team
The Animal Biotechnology Research Team has achieved important milestones by successfully producing Turkey's first clone calves and first transgenic mice (mice synthesizing human interferon, frost-resistant mice). It conducts genetic and genomic studies in farm animals, domestic and domestic animals, reproductive biology in animals, development of transgenic and experimental animal models, cancer molecular biology, identification of anticancer drug candidates, stem cell therapies, integrated omics analysis for disease diagnosis and treatment, and biodefense product development. It provides services in the field of toxicity and biocompatibility studies in experimental animals by collaborating with public research institutions, universities and private sector at national and international level.
Areas of Activity and Work
Animal Reproductive Biotechnology Studies and Development of Molecular Breeding Strategies in Livestock and Poultry
Cloning, in vitro fertilization, cryobiology, biobanking, genetic selection, etc.
Animal Genetics Studies and Pedigree Analysis
Identification of genes associated with economically important traits in farm animals, diagnosis of animal diseases such as BLAD, DUMPS where a single mutation is responsible, etc.
Cell Signaling Pathways (Apoptosis, Angiogenesis, Autophagy etc.), Molecular Cancer Biology, Anticancer Drug Development and Embryonic, Mesenchymal and Cancer Stem Cell Studies
Anti-Serum Production and Purification Studies against Pandemic Potential and Disease Causing Agents
Toxicity and Biocompatibility Studies in Experimental Animals, Development of Transgenic and Experimental Animal Models, In Vitro Model Development for Drug Development and Toxicology Studies
Pharmaceutical Technologies Research Team
The Pharmaceutical Technologies Research Team has been competent in antibody engineering, cell line development and characterization, photodynamic therapy, nanoscale drug systems, physico-chemical characterization of proteins and biological activity assays for more than 25 years. In the field of healthcare, the pharmaceutical technologies research team continues to work with different approaches in the discovery of original and biosimilar antibodies, development of new biopharmaceutical drugs, biosimilar mAbs and theranotherapeutic agents, with a priority on cancer and pathogen-induced diseases. The team carries out nationally and internationally supported multidisciplinary projects such as the development of neutralizing antibodies against Sars-CoV-2 virus, the development of the first nationally supported biosimilar antibody for cancer treatment, the production and application of photodynamic therapy agents for cancer diagnosis and treatment, and the development of nanoparticle-based molecules.
Areas of Activity and Work
Development and production of new drugs and biosimilars based on recombinant antibodies and peptides
Production in mammalian and bacterial cells.
Development of a Biotechnological Drug Producing Cell Line
Research cell bank, master cell bank and working cell bank.
Purification and Physico-Chemical Characterization of Antibodies
HPLC-based analyses (SEC, variant analysis, reverse phase, etc.), FPLC, Capillary Electrophoresis (CE-SDS, CE-IEF), SPR (Surface plasmon resonance) based affinity/kinetic biosimilarity analyses, CD, Zeta Sizer, FTIR, SDS-PAGE, Western, ELISA.
In Vitro Activity Determination of Therapeutics
Inhibition of cell proliferation/IC50/EC50 determination, cell migration/migration and invasion, Apoptosis/ROS, Wound healing assays.
3d Cell Culture, In Vitro Disease Models
Cancer, alzeimer, Type II diabetes, etc.
Directed Immunotherapeutic Applications
Screening Antibody and Peptide Libraries Against Target Antigens with Phage Display Technology
Development of Immunized, Naïve and Synthetic Human or Mouse-Based Antibody Libraries
Human and Humanoid Recombinant Antibody Engineering and Applications in Different Formats (Fab, Scfv, Nanobody, Vh, Vl)
Computer-Based Antibody Humanization
Development of Biologically Activated Materials, Implants, Nanoparticles
Determination of Virus Titer, Detection and Quantification of Neutralizing Antibodies and Antiviral Drug Screening Using the Bsl-3 Substructure
Molecular Oncology Research Team
The Molecular Oncology Research Team offers research on treatment and diagnostic methods especially for cancer, the disease of our age. Recently, it has been working on the development of diagnosis, detection and treatment systems for lung and hematologic cancers. Within the team, a bio-bank has been established from solid and liquid tissue cancer patient samples, and screening, early diagnosis, monitoring and treatment systems have been developed. Using antibodies, immuno-histochemistry kits and immunoassay systems have been developed to identify patients who are candidates for immunotherapy. A therapeutic system was also developed for the treatment of bone defects using mesenchymal stem cells and an osteomimetic hydrogel. One of the main areas of activity of the team is the development of personalized treatment systems. In this context, in addition to developing a CAR-T cell therapy system, we also aim to develop biological drugs, vaccines, small molecules and RNA therapeutics against target molecules and pathways that we have identified in collaboration with relevant expert teams within our unit and outside the institution.
Areas of Activity and Work
In Vitro Cell Culture and Lentivirus Studies
Production in mammalian and bacterial cells.
Cell Bank
Research cell bank, master cell bank and working cell bank.
Development of Chimeric Antigen Receptor (Car)-T Cell Therapy Systems
Design and expansion of CAR-T GMP-grade T cells using the ClinMACS prodigy cell production system.
Cloning Studies
Fluorescence, near infrared fluorescence and cloning of target molecules into desired cell lines or primary cells for in vitro and in vivo studies
Crispr/Cas9 Studies
TRAC locus targeted system design to prevent GvH reaction, especially in allogeneic CAR-T studies.